2025

Autism-like atypical face processing in Shank3 mutant dogs   [PDF]

Siqi Yuan, Chenyu Pang, Liang Wu, Li Yi, Kun Guo, Yong-hui Jiang, Yong Q Zhang* and Shihui Han*

Science Advances, 2025, Apr 4;11(14):eadu3793.

 

Reduced attention to human eyes in autism-associated Shank3 mutant laboratory beagle dogs. [Full Text Link]

Yumo Li, Qiandong Wang, Siqi Yuan, Tak Kwan Lam, Kun Guo, Yong Q Zhang* and Li Yi*

Molecular Psychiatry, 2025, DOI: 10.1038/s41380-025-02965-7.

Neural mechanisms underlying reduced nocifensive sensitivity in autism-associated Shank3 mutant dogs.[Full Text Link]

Qi Shi, Baolong Ren, Xuejing Lu, Libo Zhang, Liang Wu, Li Hu* and Yong Q Zhang*

Molecular Psychiatry, 2025, DOI: 10.1038/s41380-025-02952-y.

Oxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs.  [PDF ]

Wen Lyu, Yuan Li, Aiyu Yao, Qing-Quan Tan, Rong Zhang, Jian-Ping Zhao, Kun Guo, Yong-Hui Jiang, Rui Tian and Yong Q Zhang*

Translational Psychiatry, 2025, 15(1):76.

2024

Disrupted Human-Dog Interbrain Neural Coupling in Autism-Associated Shank3 Mutant Dogs  [PDF]

Wei Ren, Shan Yu, Kun Guo, Chunming Lu, and Yong Q Zhang*

Advanced Science.2024, 11, 2402493

VDGE: a data repository of variation database for gene-edited animals across multiple species  [PDF]

Wenwen Shi , Enhui Jin , Lu Fang , Yanling Sun, Zhuojing Fan, Junwei Zhu , Chengzhi Liang, Ya-Ping Zhang , Yong Q. Zhang* ,Guo-Dong Wang and Wenming Zhao

Nucleic Acids Research, 2025, Vol. 53, Database issue

Impaired tactile processing in autism-associated Shank3 mutant dogs: neural mechanism and intervention.  [PDF]

Qi Shi, Liang Wu, Baolong Ren, Kun Guo, Yong-Hui Jiang, Yong Q Zhang* and Li Hu*

Science Bulletin (Beijing), 2025, 70(4):483-487.

Impaired synaptic function and hyperexcitability of the pyramidal neurons in the prefrontal cortex of autism-associated Shank3 mutant dogs. [PDF]

Feipeng Zhu, Qi Shi, Yong hui Jiang, Yong Q Zhang* and Hui Zhao*

Molecular Autism, 2024, 15(1):9.

2023

Altered pupil responses to social and non-social stimuli in Shank3 mutant dogs. [PDF]

Wei Ren, Kang Huang, Yumo Li, Qin Yang, Liping Wang, Kun Guo, Pengfei Wei and Yong Q Zhang*

Molecular Psychiatry, 2023, 28(9):3751-3759.

Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing. [PDF]

Rui Tian, Yuan Li, Hui Zhao, Wen Lyu, Jianping Zhao, Xiaomin Wang, Heng Lu, Huijuan Xu, Wei Ren, Qing-Quan Tan, Qi Shi, Guo-Dong Wang, Ya-Ping Zhang, Liangxue Lai, Jidong Mi, Yong-Hui, Jiang* and Yong Q Zhang*

Molecular Psychiatry, 2023, 28(9):3739-3750.

Shank3 mutations enhance early neural responses to deviant tones in dogs.  [PDF]

Liang Wu, Shuting Mei, Shan Yu, Shihui Han* and Yong Q.Zhang*

Cerebral Cortex, 2023, 33(20):10546-10557.

A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury. [PDF]

Tingting Li, Wenwen Shi, Margaret S Ho* and Yong Q Zhang*

eLife. 2024, 12:RP87258.

Gbb glutathionylation promotes its proteasome-mediated degradation to inhibit synapse growth. [PDF]

Md Shafayat Hossain, AiyuYao*, Xinhua Qiao, Wenwen Shi, TingXie, Chang Chen* and Yong Q Zhang*

Journal of Cell Biology, 2023, 222(9):e202202068.

Differential effects of social isolation on oligodendrocyte development in different brain regions: insights from a canine model. [PDF]

Huilin Hong, Chao Guo, Xueru Liu, Liguang Yang, Wei Ren, Hui Zhao, YuanLi, Zhongyin Zhou, Sin Man Lam, Jidong Mi, Zhentao Zuo, Cirong Liu, Guo-Dong Wang, Yan Zhuo, Ya-Ping Zhang, Yixue Li, Guanghou Shui, Yong Q Zhang* and Ying Xiong*

Frontiers in Cellular Neuroscience, 2023, 17:1201295.

CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate. [PDF]

Bang Li, Hui Zhao, Zhuchi Tu, Weili Yang, Rui Han, Lu Wang, Xiaopeng Luo, Mingtian Pan, Xiusheng Chen, Jiawei Zhang, Huijuan Xu, Xiangyu Guo, Sen Yan, Pen gYin, Zhiguang Zhao, Jianrong Liu, Yafeng Luo, Yuefeng Li, Zhengyi Yang, Baogui Zhang, Zhiqiang Tan, Hao Xu, Tianzi Jiang, Yong-hui Jiang, Shihua Li, Yong Q Zhang* and Xiao-Jiang Li*

Cell Discovery, 2023, 9(1):27. .

Social isolation and the brain: effects and mechanisms. [PDF]

Ying Xiong, Huilin Hong, Cirong Liu and Yong Q Zhang*

Molecular Psychiatry, 2023, 28(1):191-201.

2022

A dog carrying mutations in AVP-NPII exhibits key features of central diabetes insipidus. [PDF]

Huijuan Xu, Haiyang Hao, Shirui Wang, Xueru Liu, Wen Lyu, Zhentao Zuo, Yan Zhuo, Jidong Mi, Yong Q Zhang, Rui Tian* and Huijuan Zhu*

Journal of Genetics and Genomics, 2023, 50(4):280-283.

Dog models of human atherosclerotic cardiovascular diseases. [PDF]

Hui Zhao, Enqi Liu and Yong Q Zhang*

Mammalian Genome, 2023, 34(2):262-269.

Left-right asymmetry and attractor-like dynamics of dog’s tail wagging during dog-human interactions. [PDF]

Wei Ren, Pengfei Wei, Shan Yu* and Yong Q Zhang*

iScience, 2022, 25(8):104747.

Comparative proteome and cis-regulatory element analysis reveals specific molecular pathways conserved in dog and human brains. [PDF]

Huilin Hong, Zhiguang Zhao , Xiahe Huang, Chao Guo, Hui Zhao, Guo-Dong Wang, Ya-Ping Zhang, Jian-ping Zhao, Jianhui Shi Yong-hui, Jiang, Yingchun Wang, Lei M. Li, Zhuo Du , Qing-Feng Wu , Yong Q Zhang* and Ying Xiong*

Molecular and Cellular Proteomics, 2022, 21(8):100261.

2021

The calcium-dependent protease calpain in neuronal remodeling and neurodegeneration. [PDF]

Elsayed Metwally, Guoli Zhao and Yong Q Zhang*

Trends in Neuroscience, 2021 ,44(9):741-752.

Single-cell RNA Sequencing Reveals Thoracolumbar Vertebra Heterogeneity and Rib-genesis in Pigs. [PDF]

Jianbo Li, Ligang Wang, Dawei Yu3, Junfeng Hao4, Longchao Zhang,Adeniyi C. Adeola, Bingyu Mao, Yun Gao1, Shifang Wu, Chunling Zhu, Yong Q Zhang, Jilong Ren, Changgai Mu, David M. Irwin, Lixian Wang*, Tang Hai*, Haibing Xie* and Yaping Zhang*

Genomics, Proteomics & Bioinformatics, 2021, 19(3):423-436.

计算行为学研究进展 [PDF]

任炜, 余山, 张永清*

科学通报, 2021, 66(30).

2020

Postsynaptic cAMP Signalling Regulates the Antagonistic Balance of Glutamate Receptor Subtypes. [PDF]

Kai Zhao, Huilin Hong, Lu Zhao, Sheng Huang, Ying Gao, Elsayed Metwally, Yuqiang Jiang, Stephan. Sigrist and Yong Q Zhang*

Development, 2020, 147(24):dev191874.

Ttm50 facilitates calpain activation by anchoring it to calcium stores and increasing its sensitivity to calcium. [PDF] 

Elsayed Metwally, Guoli Zhao, Qifu Wang and Yong Q Zhang*

Cell Research, 2021, 31(4):433-449.

Structural remodeling of active zones is associated with synaptic homeostasis. [PDF]

Huilin Hong, Kai Zhao, Shiyan Huang, Sheng Huang, Aiyu Yao, Yuqiang Jiang, Stephan Sigrist, Lu Zhao* and Yong Q Zhang*

Journal of Neuroscience, 2020, 40(14):2817-2827. (cover story)

Before  2020

Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates. [PDF] 

Hui Zhao, Qiqi Wang, Ting Yan, Yu Zhang, Hui-juan Xu, Hao-peng Yu, Zhuchi Tu, Xiangyu Guo,Yong-hui Jiang*, Xiao-jiang Li, HuihuiZhou* and Yong Q Zhang*

Translational Psychiatry, 2019, 9(1):267.

Drosophila homolog of the intellectual disability-related long-chain acyl-CoA synthetase 4 is required for neuroblast proliferation. [PDF]

Mingyue Jia, Danqing Meng, Mo Chen, Tingting Li, Yong Q Zhang* and Aiyu Yao*

Journal of Genetics and Genomics, 2019, 46(1):5-17.

The glycosphingolipid MacCer promotes synaptic bouton formation in Drosophila by interacting with Wnt. [PDF]

Yan Huang, Sheng Huang, Coralie Di Scala, Qifu Wang, Hans H Wandall, Jacques Fantini, Yong Q Zhang*

eLife, 2018, 7:e38183.

Calcium activated Calpain specifically cleaves glutamate receptor IIA but not IIB at the Drosophila neuromuscular junction. [PDF]

Elsayed Metwally, Guoli Zhao, Wenhua Li, Qifu Wang and Yong Q Zhang*

Journal of Neuroscience, 2019, 39(15):2776-2791.

CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms. [PDF]

Zhuchi Tu, Hui Zhao, Bang Li1,SenYan1, Lu Wang, Yongjin Tang, Zhujun Li, Dazhang Bai, Caijuan Li, Yingqi Lin,YuefengLi, Jianrong Liu, Hao Xu, Xiangyu Guo, Yong-hui Jiang, Yong Q Zhang* and Xiao-Jiang Li*

Human Molecular Genetics, 2019, 28(4):561-571.

Modeling Autism in Non-human Primates: Opportunities and Challenges. [PDF]

Hui Zhao , Yong-Hui Jiang, and Yong Q Zhang*

Autism Research, 2018, 11(5):686-694.

A pre-synaptic function of Shank protein in Drosophila. [ PDF]

Song Wu, Guangming Gan, Zhiping Zhang, Jie Sun, Qifu Wang, Zhongbao Gao, Meixiang Li, Shan Jin, Juan Huang, Ulrich Thomas, Yong-hui Jiang, Yan Li, Rui Tian* and Yong Q Zhang*

Journal of Neuroscience, 2017, 37(48):11592-11604.

Altered neurogenesis and disrupted expression of synaptic proteins in SHANK3 deficient non-human primate prefrontal cortex. [PDF]

Hui Zhao, Zhuchi Tu, Huijuan Xu, Sen Yan, Huanhuan Yan, Yinghui Zheng, Weili Yang, Jiezhao Zheng, Zhujun Li, Rui Tian, Youming Lu, Xiangyu Guo, Yong-Hui Jiang*, Xiao-Jiang Li* Yong Q Zhang*

Cell Research, 2017, 27(10):1293-1297.

Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Drosophila.[PDF]

Chuan-Xi Mao, Xue Wen, Shan Jin and Yong Q Zhang*

Disease Models and Mechanisms, 2017, 10(10):1245-1252.

Acsl, the Drosophila ortholog of intellectual disability-related ACSL4, inhibits synaptic growth by altered lipids. [PDF] 

Yan Huang, Sheng Huang, Sin Man Lam, Zhihua Liu1, Guanghou Shui and Yong Q Zhang*

Journal of Cell Science, 2016, 129(21):4034-4045.

Drosophila homolog of FMRP maintains genome integrity by interacting with Piwi. [PDF]  

Fangfang Jiang, Falong Lu, Peixue Li, Wei Liu*, Lu Zhao, Qifu Wang, Xiaofeng Cao, Lei Zhang and Yong Q Zhang*

Journal of Genetics and Genomics, 2016, 43(1):11-24. (cover story)

Angelman syndrome protein Ube3a regulates synaptic growth and endocytosis by inhibiting bone morphogenetic protein signaling in Drosophila.    [PDF]

Wenhua Li, AiyuYao*, HuiZhi, Kuldeep Kaur, Yong-chuan Zhu, Mingyue Jia, Hui Zhao, Qifu Wang, Shan Jin, Guoli Zhao, Zhi-Qi Xiong and Yong Q Zhang*

PLoS Genetics, 2016, 12(5):e1006062.

Drosophila S6 kinase like inhibits neuromuscular junction growth by downregulating the BMP receptor Thickveins. [PDF]

Guoli Zhao, Yingga Wu, Li Du, Wenhua Li, Ying Xiong, Aiyu Yao, Qifu Wang and Yong Q Zhang*

PLoS Genetics, 2015, 11(3):e1004984.

A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling. [PDF] 

Jasmin Podufall, Rui Tian, Elena Knoche, Dmytro Puchkov, Alexander M. Walter, Stefanie Rosa, Christine Quentin,  Anela Vukoja, Nadja Jung, Andre Lampe, Carolin Wichmann, Mathias Bo¨hme, Harald Depner,Yong Q Zhang, Jan Schmoranzer, Stephan J. Sigrist* and Volker Haucke*

Cell Reports, 2014, 7(5):1417-1425.

Drosophila Acyl-CoA synthetase long-chain family member 4 inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling. [PDF]

Zhihua Liu, Yan Huang,Wen Hu, Sheng Huang, Qifu Wang, Junhai Han and Yong Q Zhang*

Journal of Neuroscience, 2014, 34(8):2785-96.

Microtubule-severing protein katanin regulates neuromuscular junction development and dendritic elaboration in Drosophila. [PDF] 

Chuan-Xi Mao, Ying Xiong, Zhaohuan Xiong, Qifu Wang, Yong Q Zhang* and Shan Jin*

Development, 2014, 141(5):1064-74.

Brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing Mad expression. [PDF]

Wenwen Shi,Yan Chen, Guangming Gan, Dan Wang, Jinqi Ren, Qifu Wang, Zhiheng Xu, Wei Xie and Yong Q Zhang*

Journal of Neuroscience, 2013, 33(30):12352-63.

Drosophila cyfip regulates synaptic development and endocytosis by suppressing filamentous actin assembly. [PDF]

Lu Zhao, Dan Wang, Qifu Wang, Avital A. Roda and Yong Q Zhang*

PLoS Genetics, 2013, 9(4):e1003450.

HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. [PDF] 

Ying Xiong, Kai Zhao, Jiaxi Wua, Zhiheng Xua, Shan Jin and Yong Q Zhang*

Proc Natl Acad Sci USA, 2013, 110(12):4604-9.

RIM Promotes Calcium Channel Accumulation at Active Zones of the Drosophila Neuromuscular Junction. [PDF] 

Ethan R.Graf, Vera Valakh, Christina M. Wright,Chunlai Wu, Zhihua Liu, Yong Q Zhang and Aaron DiAntonio*

Journal of Neuroscience, 2012, 32(47):16586-96.

Drosophila FMRP participates in the DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis. [PDF]

Wei Liu, Fangfang Jiang, Xiaolin Bi* and Yong Q Zhang*

Human Molecular Genetics, 2012, 21(21):4655-68.

Drosophila acyl-CoA synthetase long-chain family member 4 regulates axonal transport of synaptic vesicles and is required for synaptic development and transmission. [PDF] 

Zhihua Liu, Yan Huang, Yi Zhang, Di Chen and Yong Q Zhang*

Journal of Neuroscience, 2011, 31(6):2052-63.

Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria. [PDF] 

Aiyu Yao, Shan Jin, Xinhai Li, Zhihua Liu, Xuehua Ma, Jing Tang and Yong Q Zhang*

Human Molecular Genetics, 2011, 20(1):51-63.

Drosophila CG10527 mutants are resistant to juvenile hormone and its analog methoprene. [PDF] 

Haiying Zhang, Ling Tian, Stephen Tobec, Ying Xiong, Songyan Wang, Xinda Lin, Yanan Liu,William Bendena, Sheng Li and Yong Q Zhang*

Biochemical and Biophysical Research Communications, 2010 , 401(2):182-7.

POSH is Involved in Egr-Bsk (TNF-JNK) Signaling and Embryogenesis in Drosophila. [PDF] 

Ming Zhang, Yong Q Zhang and Zhiheng Xu*

Journal of Genetics and Genomics, 2010, 37(9):605-19.

Distinct Presynaptic and postsynaptic dismantling processes of Drosophila neuromuscular junctions during metamorphosis. [PDF] 

Zhiwei Liu, Yan Chen, Dan Wang, Songyan Wang and Yong Q Zhang*

Journal of Neuroscience, 2010, 30(35):11624-34.

Drosophila twinfilin is required for cell migration and synaptic endocytosis. [ PDF] 

Dan Wang, Lijun Zhang, Guoli Zhao, Gudrun Wahlström, Tapio. Heino, Jiong Chen* and Yong Q Zhang*

Journal of Cell Science, 2010, 123(Pt 9):1546-56.

Drosophila tubulin chaperone E functions at neuromuscular synapses and is required for microtubule network formation. [PDF] 

Shan Jin, Luyuan Pan, Zhihua Liu, Qifu Wang, Zhiheng Xu and Yong Q Zhang*

Development, 2009, 136(9):1571-81.

Mutational analysis establishes a critical role for the N terminus of Fragile X mental retardation protein FMRP. [PDF] 

Simon P. Reeve, Xinda Lin, Bahar H. Sahin, Fangfang Jiang, Aiyu Yao, Zhihua Liu, Hui Zhi, Kendal Broadie, Wei Li, Angela Giangrande, Bassem A. Hassan and Yong Q Zhang*

Journal of Neuroscience, 2008, 28(12):3221-6.

JNK pathway: diseases and therapeutic potential. [PDF]

Jie Cui , Ming Zhang, Yong Q Zhang and Zhi-Heng Xu*

Acta Pharmacologica Sinica, 2007, 28(5):601-8.

Erectile dysfunction in Fragile X patients. [PDF] 

Feng Gu, Hai-Yin Zhang, Shao-Yi Hu, Shang-Zhi Huang, Xu Ma* and Yong Q Zhang*

Asian Journal of Andrology, 2006, 8(4):483-7.

Fathoming fragile X in fruit flies. [PDF] 

Yong Q Zhang and Kendal Broadie*

Trends in Genetics, 2005, 21(1):37-45.

Protein Expression Profiling of the Drosophila Fragile X Mutant Brain Reveals Upregulation of Monoamine Synthesis. [PDF] 

Yong Q Zhang, David B. Friedman, Zhe Wang, Elvin Woodruff, Luyuan Pan, Janis O’Donnell, and Kendal Broadie*

Molecular and Cellular Proteomics, 2005, 4(3):278-90.

The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation. [PDF] 

Luyuan Pan, Yong Q Zhang, Elvin Woodruff and Kendal Broadie*

Current Biology, 2004, 14(20):1863-70.

The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis. [PDF]

Yong Q Zhang, Heinrich J.G. Matthies, Joel Mancuso, Hillary K. Andrews, Elvin Woodruff III, David Friedman, and Kendal Broadiea*

Developmental Biology, 2004 Jun 15;270(2):290-307.

Drosophila Sec10 is required for hormone secretion but not general exocytosis or neurotransmission. [PDF] 

Hillary K. Andrews, Yong Q Zhang, Nick Trotta and Kendal Broadie*

Traffic, 2002, 3(12):906-21.

A living synaptic vesicle marker: synaptotagmin-GFP. [PDF]

Yong Q Zhang, Christopher K. Rodesch and Kendal Broadie*

Genesis, 2002 Sep-Oct;34(1-2):142-5.

Drosophila fragile X related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. [PDF] 

Yong Q Zhang, Adina M. Bailey, Heinrich J.G. Matthies, Robert B. Renden, Mark A. Smith, Sean D. Speese, Gerald M. Rubin and Kendal Broadie*

Cell, 2001, 107(5):591-603.

Drosophila D-Titin is required for myoblast fusion and skeletal muscle striation. [Full Text Link]

Yong Q Zhang, David Featherstone, Warren Davis, Emma Rushton and Kendal Broadie*

Journal of Cell Science, 2000, 113 ( Pt 17):3103-15.

Stress sensitive B encodes an adenine nucleotide translocase in Drosophila melanogaster. [PDF]

Yong Q Zhang, John Roote, Saverio Brogna, Andrew W. Davis, Daniel A. Barbash, David Nash and Michael Ashburner*

Genetics, 1999, 153(2):891-903.

One hundred and five new potential Drosophila melanogaster genes revealed through STS analysis. [PDF] 

Christos Louis*, Encarna Maduen Äo, Juan Modolell, Mahmoud M. Omar, George Papagiannakis, Robert D. C. Saunders, Charalambos Savakis, Inga SideÂn-Kiamos, Lefteris Spanos, Pantelis Topalis, Yong Q Zhang, Michael Ashburner, Panayotis Benos, Viatcheslav N. Bolshakov, Peter Deak, David M. Glover, Siegrun Herrmann and Fotis C. Kafatos

Gene, 1997, 195(2):187-93.

Cloning, mapping and tissue specific expression of Drosophila clathrin-associated protein AP50 gene. [PDF] 

Yong Q Zhang and Kendal Broadie*

Gene 233: 171-179, 1999

Identification and characterization of the gene for Drosophila L3 ribosomal protein. [PDF] 

H.Y. Edwin Chan, Yong Q Zhang, J. D. Hoheisel and Cahir J. O'Kane*

Gene, 1999, 233(1-2):171-9.

Identification and characterization of the gene for Drosophila S20 ribosomal protein. [PDF]  

H.Y. Edwin Chan, Yong Q Zhang and Cahir J. O'Kane*

Gene, 1997, 200(1-2):85-9.

An improved method of partial digestion of plant megabase DNA, suitable for YAC cloning.[ PDF] 

Guusje Bonnema , Jan Hontelez, Ruud Verkerk, Yong Q Zhang, Raymond van Daelen, Ab van Kammen and Pim Zabel*

The Plant Journal, 1996 Jan;9(1):125-33.

Page updated May 2025